This is a 4-year full-time (1.0 FTE) PhD student position. Your project will focus on the evaluation of the microarchitecture-function relationship of cartilaginous tissues of the musculoskeletal system of terrestrial and aquatic (and possibly also airborne) mammals ranging from mice and dolphins to humans, elephants and whales. Conditions related to damage to the musculoskeletal system, the principal function of which is to sustain various types of loading making the biomechanical properties of these tissues crucial for resistance against damage, are one of the main burdens to our healthcare systems. Further insight in the microarchitecture-function relationship of the cartilaginous tissues can be gained by studying the evolutionary adaptations to diverse loading conditions in a large number of species and is pivotal for an in-depth understanding of articular biology, as well as for the development of innovative, durable and functional regenerative approaches for the treatment of the very disabling disorders of these tissues that are frequently seen in the human and veterinary clinics.
You will be performing cutting-edge research on a unique collection of samples of a large range (that you will further extend) of different mammalian species available through both the Orthopedic clinic at the UMC Utrecht and Faculty of Veterinary Medicine, Utrecht University. You will use advanced imaging technologies, as well as state-of-the-art biomechanical testing set-ups. You will join the Research group at the Department of Orthopedics of the UMC Utrecht at the Regenerative Medicine Center Utrecht and closely work with the Departments of Clinical Sciences and Pathology at the Faculty of Veterinary Medicine of Utrecht University. You will coordinate your work within an (inter)national network of collaborators, while working in an ambitious, motivated, multi-disciplinary team of clinicians, veterinarians, physicists, pharmaceutical scientists, biologists, and engineers. You will co-supervise master and bachelor students during their internships and teaching opportunities will be available. You will be part of the Utrecht Graduate School of Life Sciences and will receive training, supervision, and guidance for both your research work and personal/professional development, which provides you with an excellent basis for an independent academic career.
This position is hosted at the Regenerative Medicine Center Utrecht (RMCU) and you will be appointed at the Department of Orthopedics of the UMC Utrecht. Located at the Utrecht Science Park, the RMCU brings together the largest group of researchers in regenerative medicine in the Netherlands. Our outstanding scientists, engineers, clinicians, students, ethicists and staff work closely together to translate scientific and technological discoveries into patient benefit.
The Department of Orthopedics at the UMC Utrecht is a global leader in the development and application of novel regenerative technologies, such as cell-based therapies, 3D (bio)printing, the application of biomaterials and controlled release systems, and novel imaging modalities.
The initial contract will be for a period of one year, which will be extended to a total of four year upon successful assessment
The initial contract will be for a period of one year, which will be extended to a total of four years upon successful assessment